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However, a 2015 meta-analysis, comparing cancer risk in 11 phase III trials between different available DMTs at the time, including GA, natalizumab, dimethyl fumerate, tefiluonomide, and fingolimod, demonstrated that there was not a higher cancer risk in MS patients who were treated with cladribine, but rather that due to a placebo comparator, there was an exaggerated relative increased risk in the treatment groups (151)

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Subeffective dosages of metformin combined with L-NAME and 7-NI reduced CQ-induced scratching behavior, whereas L-arginine reversed the effect, indicating the involvement of the NO pathway in pruritus [14, 15]

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