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The uncoupling proteins, upregulated by mitochondrial respiration, can reduce the production of ROS and increase the resistance towards seizure

Since BBB breakdown and vascular dysfunction are a hallmark of AD, therapeutics targeting the BBB are of great potential [136]

GHRP-2 shows appetite stimulation too, but weaker and less consistent

(-20~60C)

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This uncertainty may reflect limitations in statistical power, particularly for MR-Egger, which requires stronger assumptions and larger sample sizes to detect causal effects