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16 In the premarket drug trial on dabigatran vs warfarin among 18,000 patients with atrial fibrillation, dabigatran was either equally or more effective in reducing stroke and systemic embolism than warfarin, but produced slightly higher values of patients with myocardial infarction

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Funding This work was supported by grants from the National Natural Science Foundation of China (NSFC Numbers 81672800, 81603009, 81673020, 81802632, and 82173830), Natural Science Foundation of Shaanxi (2020JQ-445), and the Key Research and Development Program of Shaanxi Province (2021SF-207, 2021SF-223, and 2022ZDLSF05-19)

Our team strongly advises against it due to the unpredictable nature of such interactions

To validate the findings, we examined the level of AngIV after 1.44 mg/kg and 2.88 mg/kg Dihexa were administered intragastrically to the APP/PS1 group