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Weight loss was slightly lower in diabetic participants compared to non-diabetic participants in SURMOUNT-1, consistent with metabolic differences and potentially greater insulin resistance in diabetic populations

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Nevertheless, some studies have proposed that the relaxation effect of 2-agonists might be directly mediated through the interaction of Gs with potassium channels on the plasma membrane of airway smooth muscle cells (i.e., cAMP independent pathway) 176,177 (Fig