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GLP-1 drugs lead to drastic caloric restriction a type of weight loss that can cause the body to lose muscle mass

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Phase 2 Metabolic Benefits Beyond weight loss, retatrutide improved cardiometabolic markers: Blood pressure: Systolic BP decreased 7.4 mmHg (12mg dose) Triglycerides: Reduced 27% from baseline Fasting glucose: Decreased 13.8 mg/dL HbA1c: Reduced 0.4% (in participants without diabetes) TRIUMPH-4: First Phase 3 Results (December 2025) TRIUMPH-4 was the first Phase 3 trial to report

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GLP-1 receptor agonists, such as semaglutide (Ozempic, Wegovy) and liraglutide (Saxenda, Victoza), have become prominent in the management of Type 2 diabetes and weight loss