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Practical Application Start with vegetables and protein (stimulates early GLP-1 release) Follow with complex carbohydrates (sustains GLP-1 secretion) End with fruit or small dessert (if desired) Protein: 25-30% of calories Fiber-rich carbohydrates: 40-45% of calories Healthy fats: 25-30% of calories Breakfast: Greek yogurt with berries, ground flaxseed, and almonds Lunch: Grilled salmon over mixed greens with quinoa and olive oil dressing Dinner: Chicken breast with roasted vegetables and sweet potato This macronutrient distribution provides the protein and fiber necessary for GLP-1 stimulation while supporting stable blood sugar levels already within normal range

It produces even more weight loss than tirzepatide, with Phase 3 trials showing up to 28.7% body weight reduction

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It may come from preclinical data, in vitro studies, or preliminary results

Retatrutide long-term discontinuation data is still being collected, but similar weight regain is expected based on the mechanism of action