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4.1.3 Regulation of KARs by channel blockers Positively charged polyamine molecules are ubiquitously present in bacterial, plant, and animal cells and frequently function as blockers of cation-selective ion channels (Tabor and Tabor, 1984)

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haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation

The STEP trials showed significant metabolic effects beginning at this dose level