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One reason might be decomposition into chemically similar structures at higher temperatures

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Thirdly, while C3G is a natural flavonoid compound found in various fruits and vegetables and is generally considered safe for consumption as part of a regular diet, excessive intake or long-term use at high doses may pose unknown risks

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doi: 10.1161/01.atv.0000183883.72263.13

Yet over time, they cant keep up, and blood sugar rises, which is what then triggers type 2 diabetes