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5002,000 mcg once daily, titrated upward gradually across a 12-week example course

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Similarly, when increasing the minimum thresholds for average daily dose received in the analysis of MOF, differences between the two groups became larger and increasingly significant

Eur J Endocrinol (2020) 183:G2532

The most important of the inflammation-promoting pathways activated by TNF in this case are p38 MAP kinase along with NF-kB