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Instead of jumping quickly to higher doses, microdosing GLP-1 medications generally involves starting with smaller amounts or moving more gradually over time

The FDA has approved GLP-1 and related medications for chronic weight management in adults with obesity or adults with overweight and at least one weight-related condition, when used along with reduced-calorie nutrition and increased physical activity

Diabetes Care 32:14211424 Nieuwdorp M, Stroes ES, Kastelein JJ (2007) Normalization of metabolic syndrome using fenofibrate, metformin or their combination

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Among patients who stopped taking tirzepatide, 31.0% doubled their weight loss after two years, 15.2% lost some additional weight, and 9.0% maintained their initial loss, with 55.2% in total maintaining or losing more weight