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Due to the increased amount of adipose tissue, obese patients are more predisposed to systemic inflammation with higher levels of pro-inflammatory cytokines, such as interleukin 6, eotaxin-1, TNF-, transforming growth factor beta 1 (TGF-1) and CRP

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This is used for a number of vital functions as an important enzyme in the Krebs cycle, for synthesis of heme, cytochrome P450 enzymes and nucleotides

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