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[DOI] [PMC free article] [PubMed] [Google Scholar] [2].Lau CS, Mak A

Cytosolic Ca 2+ entering the mitochondrial matrix through the mitochondrial Ca 2+ uniporter (MCU) stimulates OXPHOS by activating pyruvate dehydrogenase phosphatase, which in turn, increases the activity of pyruvate dehydrogenase complex [21]

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This study provides the evidence that the synergistic effects of these complementary substances can improve insulin sensitivity and as well as liver insulin extraction and metabolic impairments in overweight/obese PCOS patients

and they suggested the effect of acylcarnitine metabolism on -oxidation in SSRI treatment response