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Medical considerations checklist: Personal or family history of medullary thyroid carcinoma or MEN 2 (contraindication for both) History of pancreatitis (use with caution

Edward Hadeler contributed to the concept, design, drafting, and editing of the manuscript

Additionally, mice eating a high-fat diet exhibited reduced intestinal guanylin expression, while re-expressing guanylin reduced the incidence of obesity-related colorectal cancer in these mice (Lin et al., 2016)

Hypoglycaemia risk is low when GLP-1 receptor agonists are used as monotherapy or with metformin, as their glucose-lowering effect is glucose-dependent

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