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For influenza A, there are at least 18 hemagglutinin (HA) and 12 neuraminidase (NA) subtypes, with group 1 and group 2 species sharing only ~37% sequence homology for HA and NA proteins and only ~25% sequence homology with influenza B species (reviewed in ref

[1] Use a new sterile needle and syringe for each withdrawal (multi-dose vial technique), and swab the rubber stopper with alcohol

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Nonresponders For all current vaccines, there is a significant population of individuals who are considered nonresponders (i.e., nonseroconverters), particularly those with an inability to mount effective B-cell responses

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