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Challenges and Limitations Research and Evidence Limitations Multiple challenges continue to constrain the current understanding of the therapeutic potential of BPC-157 and TB-500

(12(2)):100036 doi:10.1016/j.gmg.2025.100036

Patients with angiokeratomas may experience rare intermittent bleeding, pain, or pruritus

Preclinical research models have explored its interactions with angiogenic signaling, tissue response pathways, and receptor-associated biological mechanisms in small-animal and in-vitro studies

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At two years, tirzepatide yielded greater glycemic control and anthropometric benefits, with markedly higher normoglycemia rates, supporting earlier dual GIP/GLP-1 agonism when metformin response is inadequate