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In SCD, abnormal haemoglobin causes red blood cells to stiffen into a characteristic sickle shape under low-oxygen conditions

Poor preparation methods can lead to inconsistent clarity, harsh handling characteristics, and lower overall presentation quality

doi: 10.1177/1742395316644770 11 NICE

2008 May;42(5):661-9 Cescon D, Juurlink D

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After 12 hours, discard it the combination of degraded peptide and microbial growth makes injection unsafe regardless of whether you refrigerate it afterward