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After 2 d of TGR dsRNA treatment, TGR activity (using DTNB as substrate) was reduced by 35% in parasites in aerobic culture (20% O 2 ) and after 3 d of TGR dsRNA treatment, TGR activity was reduced by 61% or 63.5% in parasites cultured anaerobically or aerobically, respectively

Third Implication The third implication concerns one of the most clinically elegant mechanisms in exercise physiology, one I did not fully appreciate for years

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