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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging ( The interplay between mitochondrial function and GSH is especially critical in PD

After consideration of the aforementioned BPC 157induced changes, several applications of BPC 157 with respect to its therapeutic effects on rats with preexisting (Duzel et al., 2017

doi: 10.1158/2326-6066.CIR-18-0243 35 DornerMBrandtSTinguelyMZucolFBourquinJPZaunerLet al

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& Shastry, B

Monitoring: Glutathione treatment should be conducted clinically for maximum efficacy