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The evidence: A 2025 RCT published in Frontiers in Nutrition randomized 80 patients to 3,000 mg/day low-molecular-weight collagen peptides or placebo for 180 days

BPC-157 has been observed to have analgesic (pain-relieving) properties

Chronic heavy alcohol consumption impairs B12 status through poor dietary intake, malabsorption, and liver disease

Oh, and don't fall for brands that tell you a multi-ingredient serum is better than one with meaningful concentrations because you're getting more well-rounded support

But my clinical position remains clear: I do not recommend BPC 157 as a treatment for Crohn's disease or ulcerative colitis, and I remain highly skeptical

Around 3-8% report appetite changes, both increases and decreases have been documented