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In recent years, the anti-inflammatory effect of PDE4 inhibitors has been shown to be mainly related to PDE4B while PDE4D is related to side effects such as digestive tract symptoms

Notably, LASSS displayed additional functions to promote receptor binding-affinity and nitration resistance of HGF in a dose-dependent manner, that is high-dose LASSS in excess of a 1:4000 molar ratio to HGF, as revealed by biochemical assays after wash-out of un-reacted free LASSS (Figure 2a-d)

Phase 2/II: Phase 2 awards are often a Follow On application awarded after startups have successfully been awarded a Phase 1 proposal, have achieved the established technical merit of their R&D, and apply and compete successfully for the prototyping and field-testing Phase 2 of their project

Thekekara P, Mc S, Chungath J

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