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Hormonal imbalance : Rarely, excessive growth hormone can elevate IGF-1 beyond safe thresholds

Kouchaki E, Rafiei H, Ghaderi A, Azadchehr MJ, Safa F, Omidian K, Khodabakhshi A, Vahid F, Rezapoor-Kafteroodi B, Banafshe HR, Safa N (2024) Effects of crocin on inflammatory biomarkers and mental health status in patients with multiple sclerosis: a randomized, double-blinded clinical trial

Expert Opinion on Drug Metabolism & Toxicology, 14(10), 869877

These can include nausea, vomiting, bloating, and abdominal pain that may improve over longer-term use

Nausea or tiredness can sometimes affect activity levels short term

First, the tryptophan residue at position 1 and the peptide bonds throughout the chain are substrates for plasma peptidases, which accounts for its short half-life