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Patient acceptability of a novel upper nasal delivery system for dihydroergotamine mesylate using the Precision Olfactory Delivery (POD) device results from the open-label STOP 301 trial

How to avoid it: Because DAC extends the half-life to 8 days, injecting it frequently causes a toxic, constant "GH bleed." If researching with DAC, it should be dosed very infrequently

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Metabolic surgery appears to lead to changes in levels of adipose tissue-derived microRNAs involved in obesity, insulin resistance, systemic inflammation, and the progression from pre-diabetes to type 2 diabetes, and these changes are correlated with clinical benefits (La Sala 2020

doi:10.1016/j.jisako.2024.100380 Kamaci S, Pace JL