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Again, in the first study using FOXO4-DRI to induce apoptosis in senescent cells, the senescent cells were generated by irradiation or doxorubicin ( As shown in Figure 3, FOXO4-DRI pre-treatment is the dedifferentiation of chondrocytes during the in vitro expansion
Combining them doubles GI side effects (nausea, gastroparesis risk) with no additional benefit
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Because injectable research requires proper reconstitution with bacteriostatic water and strict aseptic technique, it is reserved for trained laboratory settings
10.1093/intimm/dxx031 Int Immunol
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