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Neuroscience 146:17951807 [DOI] [PMC free article] [PubMed] [Google Scholar] Pieyro G, Archer-Lahlou E

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1 Introduction Neurodegenerative diseases such as Alzheimers disease (AD), Parkinsons disease (PD), and multiple sclerosis (MS) are characterized by progressive nerve damage and chronic inflammation

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In intestinal epithelial cells of DSS-induced colitis mice, downregulation of the Nrf2-GPx4 signaling pathway promotes ferroptosis, while Furin protease can inhibit ferroptosis and protect intestinal epithelial cells by activating the Nrf2-GPx4 signaling pathway [282, 283]