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Certain medications : Concurrent use of other drugs associated with pancreatitis (such as certain immunosuppressants or HIV medications) requires careful consideration

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Instead, studies suggest a rapid and acute increase in intracellular calcium when KPV is introduced alongside N6-(L-2-phenyl isopropyl) adenosine (PIA), an adenosine agonist that inhibits the cAMP pathway

Solving this dosing equation during development is critical to ensure efficacy is not limited during trials an outcome that could jeopardise the chances of approval