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1 Many of the cognitive and behavioral features of ASD are believed to arise from central nervous system dysfunction, but abnormalities in many non-central nervous system tissues have been associated with ASD

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(11) These comparative studies have revealed how binding proteins regulate IGF-1 bioavailability and how the removal of IGFBP binding capacity affects biological responses

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Dimethyl sulfoxide was also efficient to reduce memory impairments in the Morris water maze test, with a drastic decrease of motor activity (also observed in the open field test), suggesting a potential side effect of sedation and/or a possible role of the treatment on behavioral disinhibition [235]

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Thus, disturbances in mitochondrial ICS biosynthesis could contribute to failures in the supply of energy (which might result in cell death) or to cancer, since genomic instability is considered as a hallmark of cancer and a driver of neoplastic transformation processes

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