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Additionally, the conversion of guanosine into uric acid can be catalyzed by guanine deaminase following guanine formation by nucleotidase [13]

Study design: Treat-to-target, randomized, double-blind, active comparator-controlled, event-driven cardiovascular outcomes trial assessing the noninferiority of once-daily Tresiba U-100 (n=3818) and once-daily insulin glargine U-100 (n=3819) in terms of the incidence of cardiovascular events

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