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Regardless of the patient's perseverance, endocrinological factors make it challenging to maintain weight once it is lost

Bras Dermatol (2016) 91:5803

Pinto, M., Brennan, L., Diehl, K., Lin, S., & Heacock, S

Off-label also contemplates a drug being given at a different dose, such as when a drug is approved at a dose of one tablet every day, but HCPs prescribe it twice daily