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Methotrexate demonstrates proven efficacy in reducing inflammation, slowing radiographic progression, and improving functional outcomes

For context, semaglutide and tirzepatide do not produce dysesthesia at clinically significant rates, though a recent paper in PMC examined allodynia and dysesthesia reports across GLP-1 medications more broadly

Medicare does not cover FDA-approved weight-management drugs for weight alone as of April 2026, and manufacturer savings cards typically exclude Medicare enrollees

Whether opting for lifestyle changes, such as gradual weight loss and exercise, or exploring advanced treatments like Sofwave, individuals can find solutions that suit their needs and preferences

Retatrutide is an investigational triple agonist still in active Phase 3 obesity development under Eli Lilly's J1I-MC-GZBJ master protocol, with no MHRA or EMA marketing authorisation as of 2026 [6][7]