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Although no head to head trials comparing tirzepatide to semaglutide 2mg exists, an adjusted indirect treatment comparison study aimed to compare these two agents based on the results from SURPASS 2 and SUSTAIN FORTE

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The implication is that there is a neuron population nucleus tractus solitarius GLP-1R neurons that can decrease appetite and cause weight loss without making individuals feel sick and so we hope that this finding will lead to the development of more selective weight loss drugs. We all know that nausea is almost always accompanied by appetite loss, and so we thought that the GLP-1 drugs may suppress appetite simply by making individuals feel nauseated

Wicher and Miazzi, 2021