Ozempic is a diabetes drug, but it became a blockbuster in recent years when doctors and patients realized that people who took it lost significant weight
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Excessive production of ROS, largely arising from mitochondrial oxidative phosphorylation, is a major driver of oxidative damage and mitochondrial dysfunction processes that correlate with MDD symptom severity, illness chronicity, cognitive impairment, and poor antidepressant response [138, 139]
MSU crystals deposit into tophi typically in cool, poorly vascularized peripheral connective tissues
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