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Long-Term Data and Research Considerations The fact is that injectable semaglutide benefits from over 14 years of clinical trial data, starting in the early 2010s, as well as extensive post-approval real-world evidence from the SUSTAIN and STEP programs

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In practical terms: Men with mild low testosterone may see normalization Men with moderate deficiencies may see partial improvement Men with severe hypogonadism often still require TRT Results depend on treatment consistency, weight loss progress, sleep quality, stress levels, and underlying medical conditions