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Month 2: Side effects usually ease, appetite reduction stabilizes, and headaches or lingering GI symptoms may appear occasionally

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10.1109/mcse.2020.3036540 280 WadeR

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[4] [14] This widespread receptor distribution explains the hormone's diverse physiological effects beyond glucose regulation

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The DAPA-HF trial was the first to establish SGLT2i efficacy in HF with reduced ejection fraction (HFrEF), enrolling 4744 patients with or without type 2 diabetes mellitus (T2DM)

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