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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

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10.1016/0028-3908(94)90039-6 Neuropharmacology 149 MuscoliC.CuzzocreaS.NdengeleM

Mao L, Lv FF, Yang WF, Zhang TF, Li ZC, Li DQ, et al

1 (2020): 131, 10.1186/s13287-020-01643-5