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The evidence suggests that without deliberate intervention, patients on GLP-1 therapies may lose a significant proportion of their weight from lean mass, a finding that has considerable implications for long-term metabolic health, physical function, and the sustainability of results. Why Muscle Mass is Not a Cosmetic Concern When patients hear the phrase muscle loss, they frequently interpret it through an aesthetic lens

Novo Nordisk did not do a great job projecting how much appetite there was for these drugs, says Levy

Starting with low GLP-1 doses while continuing established metformin therapy minimizes these effects, as the body adapts to the GLP-1 signal over weeks

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Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, et al

References 1 AbdelsamiaE