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This is the first study to show a clear benefit of GLP-1 receptor agonists on kidney failure or end-stage kidney disease, suggesting they have a key role in kidney-protective and heart-protective treatment for patients with common medical conditions like type 2 diabetes, overweight or obesity with cardiovascular disease, or CKD [chronic kidney disease], said lead author Sunil Badve, professorial fellow at The George Institute for Global Health and UNSW Sydney
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Paradoxically, this is accompanied by a BDNF-TrkB-mediated upregulation of synaptic GABA A Rs and by an 1-to-2GABA A R subunit switch, providing a mechanistic rationale for the analgesic action of the 2,3GABA A R benzodiazepine-site ligand L838,417 after nerve injury
For about 20 years, intravenous tissue plasminogen activator (IV-tPA) remained the dominant treatment until 2015, when more complex clinical trials showed favorable results in endovascular therapy (EVT) (9)
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