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10.1186/s12943-021-01464-x 50 DainaA.MichielinO.ZoeteV

9 A pooled analysis of 11 observational studies including more than 70,000 HFpEF patients reported a 5-year mortality rate of approximately 50%

It can take many years for vitamin B12 deficiency to develop due to a small daily requirement (1-2 microgram/day) and large stores of vitamin B12 in the liver

doi: 10.3389/fphar.2022.1020918 14 FangJYuanQDuZZhangQYangLWangMet al

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Factors such as aging, stress, poor diet, and environmental toxins can deplete your natural levels, making supplementation an important consideration for maintaining optimal health