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Diabetes Obes Metab 27:583594 Leiter LA, Yoon K-H, Arias P et al (2015) Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study

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It is designed to inhibit tyrosinase activity, which can shift the balance of melanin production toward pheomelanin

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