Given the relative concentrations of different ROS, the battery of H 2 O 2 -metabolizing enzymes potentially linked to glutathione, and the marked changes in glutathione status when other H 2 O 2 -metabolizing enzymes such as catalase are down-regulated, the main focus of the following discussion concerns the enzymes that could be important in linking H 2 O 2 or related peroxides to GSH oxidation to GSSG
An advisory committee to the agency last week voted in favor of widening access to six of the peptides, spurning warnings from F.D.A
IV delivery bypasses the digestive system, allowing for: Improved absorption compared with oral supplements Clinically controlled administration Predictable, accurate dosing Treatment within a medically supervised environment All infusions are delivered by trained medical professionals following established clinical protocols
Available online at: 146 WangY.WisniewskiM.MeilanR.CuiM.WebbR.FuchigamiL
Common contraindications cited in the research-use community include: anyone with active or recent cancer (BPC-157 and TB-500 promote angiogenesis), people with Wilson's disease or other copper-metabolism disorders (GHK-Cu component), anyone pregnant or breastfeeding (no safety data), and athletes subject to WADA testing (BPC-157 and TB-500 are prohibited)
Medicine has learned hard lessons from past cure-alls that went awry
