Pharmaceutical companies later developed higher-dose versions specifically for weight management, and GLP-1 medications quickly became part of the weight-loss conversation (Rosen & Ingelfinger, 2026)
In the SURPASS trials, tirzepatide demonstrated superior A1C reduction and weight loss compared to semaglutide at equivalent dose levels
The current GLP-1 drugs on the market, such as Wegovy and Zepbound, are dosed weekly, so a monthly option could be more convenient and attractive to patients
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It's important to note that endogenous GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), giving it a very short half-life in circulation