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In Eli Lilly's pivotal Phase 3 ATTAIN clinical trialsthe studies that led to FDA approvalparticipants taking orforglipron achieved average body weight reductions of approximately 7.9% to 8.7% over 36 to 40 weeks, depending on the dosing

The exocrine pancreas has GLP-1 receptors, mainly on the acinar cells

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See a healthcare provider immediately if you experience: An inability to eat Persistent or severe nausea that impacts your daily life Signs of dehydration (extreme thirst, dizziness, dry mouth, peeing less often) If your nausea is severe, consult with your prescribing physician or your GI team

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