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It mimics the action of glucagon-like peptide-1 (GLP-1), stimulating insulin release, suppressing glucagon secretion, and slowing gastric emptying

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To interrogate this, we have developed a series of in vivo models to induce Gclc deletion in adult animals

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Volume was infused through a syringeperfusion pump system (Argus 600, Argus Medical A6, Heimberg, Switzerland) (1 ml/10 s) in 10 cm colon segment with colitis and with anastomosis between 5 cm orally and 5 cm aborally, and corresponding 10 cm colon segment with colitis but without anastomosis