There are no large controlled human trials establishing combined efficacy or safety, and the pairing remains a subject of ongoing preclinical interest rather than clinical fact
Several classes of antidepressant drugs have been implicated in the serotonin syndrome, including serotonin reuptake inhibitors, tricyclic antidepressants, and monoamine oxidase inhibitors) [183,184]
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These include gastrointestinal disorders, such as Crohns disease or celiac disease, and surgeries like gastric bypass that alter the digestive tract