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provided the supervision, conceptualization, methodology, validation, and visualization of the research and participated in the writing process from the original draft preparation to the reviewing and editing of the manuscript

They are primarily regulated by the transcription factor forkhead box P3 ( FOXP3 ), which is essential for their development, function and their suppressive activity, any mutations in the FOXP3 gene can impair the Tregs activity, leading to autoimmune disorders

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