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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

N Z Med J 129 Kotilea K, Quennery S, Decros V, Hermans DA (2014) Successful sublingual cobalamin treatment in a child with short-bowel syndrome

A deficiency in vitamin B12 can cause fatigue, headaches, indigestion, problems with your vision, increased risk of obesity, and cognitive difficulties

It is an excellent supplement for energy boosting in the winter months due to lack of sunlight