In current clinical trials, retatrutide side effects have been mild to moderate and most often included: Nausea Diarrhea Vomiting Constipation As noted above, in many of these randomized trials there is a chance that you will be receiving a placebo, so no active drug at all
Coryell Health doesnt recommend taking GLP-1 medications if you: Are pregnant or breastfeeding Have a personal or family history of medullary thyroid cancer (MTC) Have a diagnosis of multiple endocrine neoplasia syndrome type 2 Have a history of pancreatitis Have severe gastrointestinal conditions Side effects of taking a GLP-1 medication may include: Loss of appetite Nausea and vomiting Diarrhea Dizziness Mildly increased heart rate Pancreatitis Medullary thyroid cancer (MTC) Acute kidney injury If youre unsure whether an existing condition, your personal history or your family history will not mix well with a GLP-1 medication, talk with your Coryell Health primary care provider to determine whether a GLP-1 medication is right for you
August 13, 2025
Three food categories have the most research behind them
The most advanced program, Daewoong Therapeutics' CLOPAM platform, achieved over 80% relative bioavailability for semaglutide versus subcutaneous injection in a 70-person Phase 1 study (August 2025)
Graphic by Clara Turnage/University Marketing and Communications For patients whose insurance wont cover GLP-1 medications, lower-cost compounded versions can seem like an attractive alternative, but the researchers urge caution
