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Simonson W, Han LF, Davidson HE (2011)
Genetic Predisposition: Some people are more predisposed to developing freckles
As for the May 2004 article's conclusion that the 1.85 value was the top of the reference range for "normal adult dogs of most breeds", the lead investigators of the 2016 EPIC Study arbitrarily concluded that only 1.7 was at the top of that reference range, thereby doubling down on arbitrariness
Not everyone will see the same effects
Though the clinical characteristics of the severe deficiency are similar to those of the granulomatosa chronic disease (EGC), its appearance happens, unlike the latter, during more advanced stages of life 17,18