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Lowered A1C of 1.7%2.0% across doses Weight loss of 16.8% in the highest dose over 40 weeks without evidence of weight loss plateau The longer duration 80-week TRIUMPH-2 will more effectively evaluate the weight loss potential of retatrutide in those with type 2 diabetes and obesity, expected to result later this year Press release: investor.lilly.com/news-releases/ Dear colleague @MWeintraubMD

The study was notable for showing that 57% of participants achieved at least 20% weight loss

Weight and ectopic-fat reduction (the dominant, indirect route)

The dosage schedule when switching after high-dose tirzepatide accounts for this partial adaptation and can help minimize the transition diarrhea

The longer food takes to digest, the slower the gastric emptying which can exacerbate any adverse gastrointestinal effects

doi: 10.1080/21604851.2025.2554040 66 HoltM