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With such an eminent authority leading the experiments no one at the time thought to question the results
Acta Diabetol (2015) 52(6):108391.10.1007/s00592-015-0792-2 14 BunckMCEliassonBCornerAHeineRJShaginianRMTaskinenMRet alExenatide treatment did not affect bone mineral density despite body weight reduction in patients with type 2 diabetes
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5,6 Additionally, high glucose levels negatively impact osteoblast function, contributing to bone defects partly through the production of advanced glycation end-products (AGEs), which upregulates sclerostin, an inhibitor of osteoblast activity
Receptors can internalize or downregulate, Hardaway said
Fusco J et al (2017): GLP-1/Exendin-4 induces -cell proliferation via the epidermal growth factor receptor
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