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p53 is involved in the regulation of more than 500 target genes and thereby controls a broad range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence Because of its pro-apoptotic function, p53 is recognized as tumour suppressor, and is found mutated in more than half of all human cancers affecting a wide variety of tissues

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10.1016/0928-4257(93)90038-u [DOI] [PubMed] [Google Scholar] Sikiric P., Rucman R., Turkovic B., Sever M., Klicek R., Radic B., et al